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Yale Doctor: Tens of thousands are dying because media is lying about HCQ

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  • Yale Doctor: Tens of thousands are dying because media is lying about HCQ

    The Key to Defeating COVID-19 Already Exists. We Need to Start Using It
    Opinion
    HARVEY A. RISCH, MD, PHD , PROFESSOR OF EPIDEMIOLOGY, YALE SCHOOL OF PUBLIC HEALTH
    ON 7/23/20 AT 7:00 AM EDT

    As professor of epidemiology at Yale School of Public Health, I have authored over 300 peer-reviewed publications and currently hold senior positions on the editorial boards of several leading journals. I am usually accustomed to advocating for positions within the mainstream of medicine, so have been flummoxed to find that, in the midst of a crisis, I am fighting for a treatment that the data fully support but which, for reasons having nothing to do with a correct understanding of the science, has been pushed to the sidelines. As a result, tens of thousands of patients with COVID-19 are dying unnecessarily. Fortunately, the situation can be reversed easily and quickly.

    I am referring, of course, to the medication hydroxychloroquine. When this inexpensive oral medication is given very early in the course of illness, before the virus has had time to multiply beyond control, it has shown to be highly effective, especially when given in combination with the antibiotics azithromycin or doxycycline and the nutritional supplement zinc.

    On May 27, I published an article in the American Journal of Epidemiology (AJE) entitled, "Early Outpatient Treatment of Symptomatic, High-Risk COVID-19 Patients that Should be Ramped-Up Immediately as Key to the Pandemic Crisis." That article, published in the world's leading epidemiology journal, analyzed five studies, demonstrating clear-cut and significant benefits to treated patients, plus other very large studies that showed the medication safety.

    Physicians who have been using these medications in the face of widespread skepticism have been truly heroic. They have done what the science shows is best for their patients, often at great personal risk. I myself know of two doctors who have saved the lives of hundreds of patients with these medications, but are now fighting state medical boards to save their licenses and reputations. The cases against them are completely without scientific merit.

    Since publication of my May 27 article, seven more studies have demonstrated similar benefit. In a lengthy follow-up letter, also published by AJE, I discuss these seven studies and renew my call for the immediate early use of hydroxychloroquine in high-risk patients. These seven studies include: an additional 400 high-risk patients treated by Dr. Vladimir Zelenko, with zero deaths; four studies totaling almost 500 high-risk patients treated in nursing homes and clinics across the U.S., with no deaths; a controlled trial of more than 700 high-risk patients in Brazil, with significantly reduced risk of hospitalization and two deaths among 334 patients treated with hydroxychloroquine; and another study of 398 matched patients in France, also with significantly reduced hospitalization risk. Since my letter was published, even more doctors have reported to me their completely successful use.

    My original article in the AJE is available free online, and I encourage readers—especially physicians, nurses, physician assistants and associates, and respiratory therapists—to search the title and read it. My follow-up letter is linked there to the original paper.

    Beyond these studies of individual patients, we have seen what happens in large populations when these drugs are used. These have been "natural experiments." In the northern Brazil state of Pará, COVID-19 deaths were increasing exponentially. On April 6, the public hospital network purchased 75,000 doses of azithromycin and 90,000 doses of hydroxychloroquine. Over the next few weeks, authorities began distributing these medications to infected individuals. Even though new cases continued to occur, on May 22 the death rate started to plummet and is now about one-eighth what it was at the peak.

    A reverse natural experiment happened in Switzerland. On May 27, the Swiss national government banned outpatient use of hydroxychloroquine for COVID-19. Around June 10, COVID-19 deaths increased four-fold and remained elevated. On June 11, the Swiss government revoked the ban, and on June 23 the death rate reverted to what it had been beforehand. People who die from COVID-19 live about three to five weeks from the start of symptoms, which makes the evidence of a causal relation in these experiments strong. Both episodes suggest that a combination of hydroxychloroquine and its companion medications reduces mortality and should be immediately adopted as the new standard of care in high-risk patients.

    Why has hydroxychloroquine been disregarded?

    First, as all know, the medication has become highly politicized. For many, it is viewed as a marker of political identity, on both sides of the political spectrum. Nobody needs me to remind them that this is not how medicine should proceed. We must judge this medication strictly on the science. When doctors graduate from medical school, they formally promise to make the health and life of the patient their first consideration, without biases of race, religion, nationality, social standing—or political affiliation. Lives must come first.

    Second, the drug has not been used properly in many studies. Hydroxychloroquine has shown major success when used early in high-risk people but, as one would expect for an antiviral, much less success when used late in the disease course. Even so, it has demonstrated significant benefit in large hospital studies in Michigan and New York City when started within the first 24 to 48 hours after admission.

    In fact, as inexpensive, oral and widely available medications, and a nutritional supplement, the combination of hydroxychloroquine, azithromycin or doxycycline, and zinc are well-suited for early treatment in the outpatient setting. The combination should be prescribed in high-risk patients immediately upon clinical suspicion of COVID-19 disease, without waiting for results of testing. Delays in waiting before starting the medications can reduce their efficacy.

    Third, concerns have been raised by the FDA and others about risks of cardiac arrhythmia, especially when hydroxychloroquine is given in combination with azithromycin. The FDA based its comments on data in its FDA Adverse Event Reporting System. This reporting system captured up to a thousand cases of arrhythmias attributed to hydroxychloroquine use. In fact, the number is likely higher than that, since the reporting system, which requires physicians or patients to initiate contact with the FDA, appreciably undercounts drug side effects.

    But what the FDA did not announce is that these adverse events were generated from tens of millions of patient uses of hydroxychloroquine for long periods of time, often for the chronic treatment of lupus or rheumatoid arthritis. Even if the true rates of arrhythmia are ten-fold higher than those reported, the harms would be minuscule compared to the mortality occurring right now in inadequately treated high-risk COVID-19 patients. This fact is proven by an Oxford University study of more than 320,000 older patients taking both hydroxychloroquine and azithromycin, who had arrhythmia excess death rates of less than 9/100,000 users, as I discuss in my May 27 paper cited above. A new paper in the American Journal of Medicine by established cardiologists around the world fully agrees with this.

    In the future, I believe this misbegotten episode regarding hydroxychloroquine will be studied by sociologists of medicine as a classic example of how extra-scientific factors overrode clear-cut medical evidence. But for now, reality demands a clear, scientific eye on the evidence and where it points. For the sake of high-risk patients, for the sake of our parents and grandparents, for the sake of the unemployed, for our economy and for our polity, especially those disproportionally affected, we must start treating immediately.

    Harvey A. Risch, MD, PhD, is professor of epidemiology at Yale School of Public Health.

    The views expressd in this article are the writer's own.

    https://www.newsweek.com/key-defeati...pinion-1519535

  • #2

    https://academic.oup.com/aje/article...waa093/5847586

    Comment


    • #3
      I would say that I'm stunned, but I'm not stunned. I've watched the media lie about this and have known they were lying from the beginning. Sadly, this is what I expect from the media anymore. The number of people who have died because of the bullying campaign to stop a treatment that Trump suggested early on is... I mean - wow.

      Comment


      • #4
        Just to be clear, none of this has anything to do with the claims Trump made about HCQ, which basically amounted to him saying it was a cure, even for advanced cases. Studies were done that showed that categorically wasn't the case. If it has some benefits for cases before the virus gets out of hand that's great, but it does nothing to change that Trump idiotically and irresponsibly promoted a dangerous drug well before anything was known one way or the other about its effectiveness against the virus.

        Comment


        • #5
          Trump never said it was a cure for advanced cases. As Dr. Risch notes, the media has misrepresented that. It was only ever suggested as a front line early treatment.

          Trump was right, and you can't change that. People were killed because the politics didn't line up for the left owned media.

          Comment


          • #6
            Originally posted by Agamemnon View Post

            If it has some benefits for cases before the virus gets out of hand...
            "some benefits."

            ...it veritably cures it before the virus gets out of hand....

            Comment


            • #7
              Also, Trump's FDA is saying this about HCQ:

              July 1, 2020 Update: A summary of the FDA review of safety issues with the use of hydroxychloroquine and chloroquine to treat hospitalized patients with COVID-19 is now available. This includes reports of serious heart rhythm problems and other safety issues, including blood and lymph system disorders, kidney injuries, and liver problems and failure.

              June 15, 2020 Update: Based on ongoing analysis and emerging scientific data, FDA has revoked the emergency use authorization (EUA) to use hydroxychloroquine and chloroquine to treat COVID-19 in certain hospitalized patients when a clinical trial is unavailable or participation is not feasible. We made this determination based on recent results from a large, randomized clinical trial in hospitalized patients that found these medicines showed no benefit for decreasing the likelihood of death or speeding recovery. This outcome was consistent with other new data, including those showing the suggested dosing for these medicines are unlikely to kill or inhibit the virus that causes COVID-19. As a result, we determined that the legal criteria for the EUA are no longer met. Please refer to the Revocation of the EUA Letter and FAQs on the Revocation of the EUA for Hydroxychloroquine Sulfate and Chloroquine Phosphate for more information.
              https://www.fda.gov/drugs/drug-safet...tal-setting-or

              The notion that this is some kind of media-based attack on Trump or a politicization of HCQ is a joke.

              Comment


              • #8
                TJAnon trying to maintain that .000 average!

                Comment


                • #9
                  Here's me on May 22nd of this year:

                  Originally posted by Taco John View Post

                  No one has ever said that HCQ is worth taking after a cytokine storm. It's always been claimed to be great for stopping viral replication at the early stages of infection, and when taken with zinc. These studies showing what happens with very sick patients are purposefully misleading.

                  You guys are going to froth and writhe, but you were wrong. You were too involved in the politics of it to see the truth.

                  Comment


                  • #10
                    Here's me posting the science on 5/19

                    Originally posted by Taco John View Post


                    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/


                    And for the people who say "der, that is SARS-covid-1, this is SARS-covid-2," science already shows that HCQ has the same effect on SARS-covid-2.






                    https://www.nature.com/articles/s41421-020-0156-0

                    Comment


                    • #11
                      Originally posted by Taco John View Post
                      Here's me on May 22nd of this year:




                      You guys are going to froth and writhe, but you were wrong. You were too involved in the politics of it to see the truth.
                      Snicker.

                      You have ZERO credibility.

                      Comment


                      • #12
                        Meanwhile, here in reality...


                        FDA ends emergency use of hydroxychloroquine for coronavirus

                        The agency now believes that the suggested dosing regimens "are unlikely to produce an antiviral effect," FDA chief scientist Denise Hinton said in a letter.

                        https://www.politico.com/news/2020/0...319872?cid=apn

                        FDA withdraws emergency use authorization for hydroxychloroquine

                        The Food and Drug Administration (FDA) has withdrawn the emergency use authorization for two controversial coronavirus treatment drugs promoted by President Trump because of serious safety issues.

                        The agency said recent clinical trial failures mean chloroquine and hydroxychloroquine may not be effective at treating COVID-19 or preventing it in people who have been exposed, and that their potential benefits do not outweigh the risks.

                        https://thehill.com/policy/healthcar...oxychloroquine


                        WHO temporarily halts trial of hydroxychloroquine over safety concerns

                        The group wants to "be proactive, err on the side of caution" when it comes to the malaria drug's use in treating COVID-19.

                        The World Health Organization announced Monday that it's suspending a trial of hydroxychloroquine in treating COVID-19, saying fears of the drug's potential danger are is causing it to "err on the side of caution."

                        The medication, best known for use against malaria and autoimmune disorders, has been touted as a possible answer to COVID-19 by President Donald Trump, who said Sunday that he had "just finished" taking the drug after a two-week course.

                        But WHO Director-General Tedros Adhanom Ghebreyesus said evidence has shown harmful side effects, including heart problems.

                        Tedros cited the British journal The Lancet which published findings Friday showing that hydroxychloroquine doesn't help COVID-19 patients and might even increase deaths.

                        "The executive group has implemented a temporary pause of the hydroxychloroquine arm within the Solidarity Trial while the safety data is reviewed by the data safety monitoring board. The other arms of the trial are continuing,” Tedros said in an online briefing from Geneva.

                        Dr. Soumya Swaminathan, the WHO's chief scientist, said the organization's investigators and regulators in individual countries have raised enough red flags to prompt the halt.

                        https://www.nbcnews.com/news/world/w...cerns-n1214341

                        Comment


                        • #13
                          TJAnon is waaaaay over quota on the wrong this year.

                          Comment


                          • #14
                            For those saying that HCQ is "dangerous"

                            Originally posted by Taco John View Post
                            Actually, you didn't read far enough. It's been used safely and extensively for years:





                            Dr. Risch also addresses this dangerous lie:
                            Third, concerns have been raised by the FDA and others about risks of cardiac arrhythmia, especially when hydroxychloroquine is given in combination with azithromycin. The FDA based its comments on data in its FDA Adverse Event Reporting System. This reporting system captured up to a thousand cases of arrhythmias attributed to hydroxychloroquine use. In fact, the number is likely higher than that, since the reporting system, which requires physicians or patients to initiate contact with the FDA, appreciably undercounts drug side effects.

                            But what the FDA did not announce is that these adverse events were generated from tens of millions of patient uses of hydroxychloroquine for long periods of time, often for the chronic treatment of lupus or rheumatoid arthritis. Even if the true rates of arrhythmia are ten-fold higher than those reported, the harms would be minuscule compared to the mortality occurring right now in inadequately treated high-risk COVID-19 patients.

                            https://www.newsweek.com/key-defeati...pinion-1519535

                            Comment


                            • #15
                              Originally posted by W*GS View Post

                              Snicker.

                              You have ZERO credibility.
                              Froth and writhe all you want. The truth is the truth, even when you deny it.

                              Comment

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