Things can change quickly in the NFL. KC wins @NO and they're still going to have a very excited stadium against SD the following week. As much as I'd love for it to become a two team race between us and SD, wouldn't count out KC yet.
I'd be surprised to see Pioli get fired as well, simply because he supposedly does a good job making money for the team, or that seems to be the belief (by those that think they're in the know like Kent Babb, Sam Mellinger, etc)
Still, if the team continues to get embarrassed and they have a 0-2 win season, it's possible. If fans stop going to games, it is possible.