Here's the base lineup I go with:
DT: Warren, Bunkley
CB: Bailey, Goodman
In the Nickle formations, quick sub so that Woodyard and DJ are your LBs in, the dime formations quick sub so that DJ is the LB.
I manually control Von from his DE spot, but I audible him to spy every play, stand him up, shift the DL to the side I'm moving him from, and pick a gap to blitz. By audibling his assignment to Spy, you can take control of another player if you need to and he'll stick with the QB.
They're not a great defense and can be really had if you play a team with fast RB who likes to run toss sweeps - but if you get a pass happy opponent (most online Madden gamers) you can get after the QB pretty good.