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PaintballCLE
06-12-2009, 07:58 PM
http://www.csuohio.edu/class/com/clevelandstater/news/news110104.html


Just as Sir Alexander Fleming unexpectedly discovered penicillin while studying bacteria more than 80 years ago, Cleveland State University’s Dr. Michael Kalafatis has discovered a potential cure for cancer while studying blood coagulation.


The treatment drug is a kinase inhibitor, an enzyme that is able to interfere with the abnormal cell growth associated with cancer. The inhibitor has successfully stopped uncontrolled cell proliferation in many different types of cancer cells in tests performed at both CSU and the Cleveland Clinic.


The clinic tested the treatment in lab cultures on leukemia, breast cancer, skin cancer, renal cancer, brain cancer and prostate cancer cells. Each time, the cell growth not only stopped, but the existing abnormal cells died, according to a CSU research office document.


Focusing on brain and breast cancer, the Cleveland Clinic has already successfully tested the drug on mice. According to the CSU Office of Sponsored Research Programs and Research, the chemical not only stopped the cancer cells from growing, it also did not cause any noticeable side effects or kill the mice.

continued....

FireFly
06-12-2009, 08:05 PM
This would be spectacular, and it sounds great. But I'm always leery just because you hear about these new cure fairly regularly and then inevitably they don't work as advertised in preliminary trials and then its back to the drawing board.

But here's holding out hope :)

PaintballCLE
06-12-2009, 08:12 PM
This would be spectacular, and it sounds great. But I'm always leery just because you hear about these new cure fairly regularly and then inevitably they don't work as advertised in preliminary trials and then its back to the drawing board.

But here's holding out hope :)

very true, but the fact its working on mice with no side effects is pretty good news. I normally don't post this kinda stuff, but since i go to and work full time at cleveland state univ figured i would. lol

BABronco
06-12-2009, 08:15 PM
we can only hope

lazarus4444
06-12-2009, 10:57 PM
i just put his name on google alerts for when he "accidently" dies it may be reported. I can't find anything on this guy on the web though, interesting. I hope its true because i had cancer and if it comes back i don't want to deal with all the **** again.

Karenin
06-13-2009, 12:27 AM
i just put his name on google alerts for when he "accidently" dies it may be reported.

::)

Let me guess, you're also a 9/11 truther?

Kaylore
06-13-2009, 02:57 AM
::)

Let me guess, you're also a 9/11 truther?

And probably believes there is an engine that runs on water available but Conoco bought the patent and locked it in a safe.

PaintballCLE
06-13-2009, 03:15 AM
i just put his name on google alerts for when he "accidently" dies it may be reported. I can't find anything on this guy on the web though, interesting. I hope its true because i had cancer and if it comes back i don't want to deal with all the **** again.

don't worry the ciggarette companies will fund him, and keep him safe. :thumbs:

Rohirrim
06-13-2009, 08:41 AM
And probably believes there is an engine that runs on water available but Conoco bought the patent and locked it in a safe.

It was Exxon Mobil that bought it. :peace:

Bronx33
06-13-2009, 09:13 AM
And probably believes there is an engine that runs on water available but Conoco bought the patent and locked it in a safe.



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gyldenlove
06-13-2009, 09:40 AM
Not the first time they have had these kind of results, we have been able to cure mice with cancer for many years, most therapies just won't translate to humans for a number of reason, and most therapies that do translate are stalls at best, the tumor keeps mutating and eventually the receptor the drug binds to will be blocked.

Bronx33
06-13-2009, 09:48 AM
If it does pan out to work it will be priced so high only a few will have it's benefits ( the american way)

Captain 'Dre
06-13-2009, 09:52 AM
This would be spectacular, and it sounds great. But I'm always leery just because you hear about these new cure fairly regularly and then inevitably they don't work as advertised in preliminary trials and then its back to the drawing board.

But here's holding out hope :)

Here's a necesary thing to consider: Cancer isn't ONE thing. There are over 200 different kinds of cancer, and it doesn't make sense that ALL types of cancer would respond to ONE treatment.

Still, highly encouraging!

Captain 'Dre
06-13-2009, 09:54 AM
If it does pan out to work it will be priced so high only a few will have it's benefits ( the american way)

Yeah... the government can sell it buy the dose to the highest bidders and apply the profits against the national debt. :sarcasm:

UberBroncoMan
06-13-2009, 10:02 AM
don't worry the ciggarette companies will fund him, and keep him safe. :thumbs:

Hell I know I would. Think of being able to keep all those lung cancer deaths from happening so those people can keep buying cigarettes.

If it does pan out to work it will be priced so high only a few will have it's benefits (the american way)

lol mmk. Tell that to oh so expensive penicillin that's save countless lives since its discovery. Expensive **** is expensive, the end. Something as simple as a drug to cure something won't be so high few can have it's benefits because guess what... CANCER DOESN'T CHOSE WHO TO ATTACK BASED ON SOCIAL STATUS. Current treatment for cancer is long arduous, and far more complicated than a drug. If they market a drug to the vastly fewer rich people who get cancer they will lose money.

Bronx33
06-13-2009, 10:12 AM
Hell I know I would. Think of being able to keep all those lung cancer deaths from happening so those people can keep buying cigarettes.



lol mmk. Tell that to oh so expensive penicillin that's save countless lives since its discovery. Expensive **** is expensive, the end. Something as simple as a drug to cure something won't be so high few can have it's benefits because guess what... CANCER DOESN'T CHOSE WHO TO ATTACK BASED ON SOCIAL STATUS. Current treatment for cancer is long arduous, and far more complicated than a drug. If they market a drug to the vastly fewer rich people who get cancer they will lose money.



Just help people don't bleed them dry (http://www.nytimes.com/2006/02/15/business/15drug.html)

STBumpkin
06-13-2009, 11:16 AM
Here's a necesary thing to consider: Cancer isn't ONE thing. There are over 200 different kinds of cancer, and it doesn't make sense that ALL types of cancer would respond to ONE treatment.

Still, highly encouraging!

Yes, there are 200 different types of cancer, but almost all of them involve uncontrolled growth of cells, which the drug in this article stops and kills.

STBumpkin
06-13-2009, 11:19 AM
Just help people don't bleed them dry (http://www.nytimes.com/2006/02/15/business/15drug.html)

This is evil. How can the executives of this company sleep at night?

BroncoBuff
06-13-2009, 11:25 AM
Guy might not be a quack ... there's another researcher with similar results who was profiled on 60 Minutes:

http://www.cbsnews.com/stories/2008/04/10/60minutes/main4006951.shtml

Bronx33
06-13-2009, 11:53 AM
This is evil. How can the executives of this company sleep at night?


They don't care and neither do the hospitals whom buy the drugs fairly cheap and then turn around and charge the patient out the wazoo for treatment ( it's basically a monopoly/extortion) i wish it were different but sadly it isn't.

Paladin
06-13-2009, 01:32 PM
This is why Health Care Reform scares the crap out of the industry "leaders".

To curb many of these excesses, all the Congress has to do is allow Medicare and Medicaid to negotiate drug prices with the companies......

Bronx33
06-13-2009, 02:40 PM
This is why Health Care Reform scares the crap out of the industry "leaders".

To curb many of these excesses, all the Congress has to do is allow Medicare and Medicaid to negotiate drug prices with the companies......


Wouldn't it be nice if congress did the right thing for once iam sick and tired of being a walking wallet that doesn't have unlimited funds heres an example rarely i get a little asthma so i get an inhaler which was 10.00 bucks well this year they have a new fancy one and i get a prescription and when i go to get it the f**** is 50.00! i said never mind i will suffer.

Elway777
06-13-2009, 03:55 PM
Another possibly treatment for Cancer is DCA http://rds.yahoo.com/_ylt=A0oGk9_XHjRKU3YBGX9XNyoA;_ylu=X3oDMTByZWgwN28 5BHNlYwNzcgRwb3MDMQRjb2xvA3NrMQR2dGlkAw--/SIG=11es1g4rj/EXP=1245016151/**http%3a//www.thedcasite.com/ My Dad had the worst type of Cancer small cell lung cancer and was stage 4 with 2 months to live . My dad went to canada and got DCA plus added high doses of COq10 plus high doses of grape extract and the Cancer was all gone in 3 weeks. Nobody can potent the drug rights to DCA so may never get FDA approval.

Bronx33
06-13-2009, 03:59 PM
Another possibly treatment for Cancer is DCA http://rds.yahoo.com/_ylt=A0oGk9_XHjRKU3YBGX9XNyoA;_ylu=X3oDMTByZWgwN28 5BHNlYwNzcgRwb3MDMQRjb2xvA3NrMQR2dGlkAw--/SIG=11es1g4rj/EXP=1245016151/**http%3a//www.thedcasite.com/ My Dad had the worst type of Cancer small cell lung cancer and was stage 4 with 2 months to live . My dad went to canada and got DCA plus added high doses of COq10 plus high doses of grape extract and the Cancer was all gone in 3 weeks. Nobody can potent the drug rights to DCA so may never get FDA approval.


Glad to hear your dad beat it too bad red tape keeps it in the dark for the others.

Elway777
06-13-2009, 04:04 PM
http://www.csuohio.edu/class/com/clevelandstater/news/news110104.html


Just as Sir Alexander Fleming unexpectedly discovered penicillin while studying bacteria more than 80 years ago, Cleveland State University’s Dr. Michael Kalafatis has discovered a potential cure for cancer while studying blood coagulation.


The treatment drug is a kinase inhibitor, an enzyme that is able to interfere with the abnormal cell growth associated with cancer. The inhibitor has successfully stopped uncontrolled cell proliferation in many different types of cancer cells in tests performed at both CSU and the Cleveland Clinic.


The clinic tested the treatment in lab cultures on leukemia, breast cancer, skin cancer, renal cancer, brain cancer and prostate cancer cells. Each time, the cell growth not only stopped, but the existing abnormal cells died, according to a CSU research office document.


Focusing on brain and breast cancer, the Cleveland Clinic has already successfully tested the drug on mice. According to the CSU Office of Sponsored Research Programs and Research, the chemical not only stopped the cancer cells from growing, it also did not cause any noticeable side effects or kill the mice.

continued.... Sounds like a great treatment for cancer and hope the Drug is patentable because it will never see the light of day unless someone can make billions on it. FDA is owned by the drug industry.

HILife
06-13-2009, 04:23 PM
I hope they find a cure for cancer. One of my old bosses died of cancer a month ago.

DBroncos4life
06-13-2009, 04:28 PM
And probably believes there is an engine that runs on water available but Conoco bought the patent and locked it in a safe.

It was GM and they are going to break it out now that everyone is broke.

alchemize
06-13-2009, 06:14 PM
Wow, article date is the same day my father-in-law found out he has prostate cancer.

epicSocialism4tw
06-13-2009, 06:15 PM
This research is interesting, and there are boucoups of other research groups out there who are on to cancer as well. You can mark the cancer cells with proteins that will be recognized and destroyed by the immune system, and there are several other ways to approach the problem.

However, the difficult part is getting through testing. Human testing is very difficult to perform with an acceptable sampling.

Bronx33
06-13-2009, 06:18 PM
This research is interesting, and there are boucoups of other research groups out there who are on to cancer as well. You can mark the cancer cells with proteins that will be recognized and destroyed by the immune system, and there are several other ways to approach the problem.

However, the difficult part is getting through testing. Human testing is very difficult to perform with an acceptable sampling.



Some folks have zero time for testing and have no choice what's the difference let em try it with a consent of course but they are not even givin that opportunity.

BroncoBuff
06-13-2009, 06:21 PM
Nobody can potent the drug rights to DCA so may never get FDA approval.

CoQ10 and grape-seed extract don't need patents ... they're already popular supplements.

epicSocialism4tw
06-13-2009, 06:26 PM
Some folks have zero time for testing and have no choice what's the difference let em try it with a consent of course but they are not even givin that opportunity.

Testing is done with bunches of people. It has to be government sanctioned.

Its dangerous because people die in testing. It happens even today with vaccines (albeit rarely...and hard to prove in court). If a treatment results in death, the drug company deep-sixes the project.

Bronx33
06-13-2009, 06:28 PM
Testing is done with bunches of people. It has to be government sanctioned.

Its dangerous because people die in testing. It happens even today with vaccines (albeit rarely...and hard to prove in court). If a treatment results in death, the drug company deep-sixes the project.

I doubt they deep six it ( but maybe they do) but wouldn't you think adjustments could be learned and adjusted? ( just brain storming)

epicSocialism4tw
06-13-2009, 07:19 PM
I doubt they deep six it ( but maybe they do) but wouldn't you think adjustments could be learned and adjusted? ( just brain storming)

Well, the problem is with cost. The industry is set up to where drug companies (these people do the bulk of the heavy lifting) are vulnerable when testing results in a product that isnt viable. the product has to be scrapped basically because of liability if and when something went wrong with the next round. Its a convoluted process.

Bronx33
06-13-2009, 07:31 PM
Well, the problem is with cost. The industry is set up to where drug companies (these people do the bulk of the heavy lifting) are vulnerable when testing results in a product that isnt viable. the product has to be scrapped basically because of liability if and when something went wrong with the next round. Its a convoluted process.


Exactly a price has been put on human life and if you have the cash ( you might live a bit longer) which i think is BS. FACT IS people suck.

epicSocialism4tw
06-13-2009, 07:36 PM
Exactly a price has been put on human life and if you have the cash ( you might live a bit longer) which i think is BS. FACT IS people suck.

Well, the truth of the matter is that resources drive research. There has to be monetary incentive to stimulate the best r&d. The best chemists, pharmacologists, genetics researchers, etc. work in private industry and make lots of money. If they didnt make it there, they would make it somewhere else. They make lots of money because what they do is extremely valuable.

Bronx33
06-13-2009, 07:50 PM
Well, the truth of the matter is that resources drive research. There has to be monetary incentive to stimulate the best r&d. The best chemists, pharmacologists, genetics researchers, etc. work in private industry and make lots of money. If they didnt make it there, they would make it somewhere else. They make lots of money because what they do is extremely valuable.


Funny thing is all the cash should be directed to solving the cancer problem ( there really shouldn't be a price put on research ( JUST GET IT DONE)

epicSocialism4tw
06-13-2009, 08:19 PM
Funny thing is all the cash should be directed to solving the cancer problem ( there really shouldn't be a price put on research ( JUST GET IT DONE)

There is a price on everything.

People are motivated by how the job can help them and their family. There's nothing wrong with that.

Bronx33
06-13-2009, 08:22 PM
There is a price on everything.

People are motivated by how the job can help them and their family. There's nothing wrong with that.


I have a problem when a price is put on ( benefit of mankind)

epicSocialism4tw
06-13-2009, 08:29 PM
I have a problem when a price is put on ( benefit of mankind)

There is a price on everything. Everything has a cost.

Bronx33
06-13-2009, 08:30 PM
There is a price on everything. Everything has a cost.




Ans while that's debated people die.

epicSocialism4tw
06-13-2009, 08:35 PM
Ans while that's debated people die.

Well, businesses have a bottom line so that they can ensure their own survival. This includes the survival of all of those jobs. It would do no good if they just threw their money away. A business should be a machine that creates resources for its employees by maintaining services for people.

If a business doesnt make its employees money, those employees leave and go somewhere else.

gyldenlove
06-13-2009, 08:39 PM
Well, the problem is with cost. The industry is set up to where drug companies (these people do the bulk of the heavy lifting) are vulnerable when testing results in a product that isnt viable. the product has to be scrapped basically because of liability if and when something went wrong with the next round. Its a convoluted process.

There are several more problems to the way phase III trials are run today.

Firstly you need a massive cohort, so that requires multi center and often internation collaboration, you need very strong protocols so everybody performs their tests and follow ups the same way, you need ethics approval as well as solid phase II data in limited clinical trials and animal trials.

Secondly you need enough people involved in the data process that you can continuously evaluate the efficacy, so if it is necesary the trial can be terminated with minimal damages.

Thirdly and this is the real killer, if you offer someone a treatment, you are obligated to pay for that treatment for as long as that patient needs it, meaning that if the patient falls ill again later you are on the hook for their bills. It also means that if you give a very expensive experimental drug you have to keep providing it to patients long after the study is over if they request it. You also have to pay for the treatment of any symptoms or diseases that are potentially caused by the trial, not only the cases that can be proven to be a consequence of the trial, but also the ones that have some limited chance of being caused by the trial.

A good phase III trial can cost upwards of 1 billion dollars to perform. There is a limit to how many companies can afford that if the drug isn't usable in a wide enough group of patients and if the drug doesn't promise to bring in big bucks.

Elway777
06-13-2009, 08:54 PM
CoQ10 and grape-seed extract don't need patents ... they're already popular supplements. They are not approved by the Fda for cancer treatment and it would take billion to get Fda approval. Their are alot of things that might help fight cancer but may never be use because of the high cost of trails and getting Fda approve. It takes at least a billion dollars or more to get a drug approved by Fda and that is why Drug companies have to change high prices for their drugs . So even if Co enyme Q10 and Grape extract could help make Dca or another chemotherapy drug work better , a Doctor could not use it because it is not Fda appoved. I read a study that mice given Co enyme Q10 plus Chemotherapy that 90% of the mice lived. The Mice that given just Chemotherapy only 30 % lived. I thing the Fda is the biggest hindrance in finding better treatments for Cancer. You can take Co enymeQ10 and Grape extract on your own. I would take at least 200mg a day for both if worried about cancer . I think it is almost impossible to get cancer if you are taking 200 mg of both but I have no evidence to back me up.,

TheReverend
06-13-2009, 08:58 PM
Curing cancer would be such a boon to modern civilization.

Things that scare me:
Spiders
Josh McDaniels
Cancer

If they cure it, I'm gonna start dipping even heavier than I do now. I'll sleep with it in!

epicSocialism4tw
06-13-2009, 09:04 PM
Thirdly and this is the real killer, if you offer someone a treatment, you are obligated to pay for that treatment for as long as that patient needs it, meaning that if the patient falls ill again later you are on the hook for their bills. It also means that if you give a very expensive experimental drug you have to keep providing it to patients long after the study is over if they request it. You also have to pay for the treatment of any symptoms or diseases that are potentially caused by the trial, not only the cases that can be proven to be a consequence of the trial, but also the ones that have some limited chance of being caused by the trial.


Yep.

You went into more detail than I wanted to, and with far fewer words. ;D

It is very hard to have a lawyer prove to a jury a link between the side effect and the drug because of the standard error in computing the data with such a large sample size, but if it so happens that a jury makes that decision...see ya Pharma. That company could very well be toast...especially if some of those cases result in death.

Elway777
06-16-2009, 12:03 AM
http://www.cancerquest.org/index.cfm?page=185 their are several new drugs that attact proteins in only cancer cell . These drugs combined with chemotherapy could be a good treatment for cancer.
I still like my treatment I develope for my Dad. 10 mg Dca + 600 mg of CoenymeQ1o and 400 mg of Grape extract. DCA attacts a enyme in cancer cells that it uses for Gycolysis which turns on the mitchotronia in cancer cell causing the cell to committ suicide. The Coenyme Q10 is a stong anti oxidant that kills damage cell and and produces large amouts of oxygen which futher activate the mitchotonia in cancer cells. Grape Extract also has a large amouts of anti oxidants that attact cancer cells.